Publications

(2017)

The long noncoding RNA Wisper controls cardiac fibrosis and remodeling.

Micheletti R, Plaisance I, Abraham BJ, Sarre A, Ting CC, Alexanian M, Maric D, Maison D, Nemir M, Young RA, Schroen B, González A, Ounzain S, Pedrazzini T.

Sci Transl Med. 2017 June; PMID: 28637928

 

New Lncs to mesendoderm specification.

Alexanian M, Pedrazzini T, Ounzain S.

J Thorac Dis. 2017 Mar; PMID: 28446963

 

 


(2016)

Cardiomyocyte lineage specification in adult human cardiac precursor cells via modulation of enhancer associated long noncoding RNA expression

Plaisance, I., S. Perruchoud, M. Fernandez, C. Gonzales, S. Ounzain, P. Ruchat, M. Nemir, E. Niggli, and Thierry Pedrazzini.

JACC Basic to Translational Science. 2016.

 

 

Cardiac mTOR complex 2 preserves ventricular function in pressure-overload hypertrophy.

Shende P, Xu L, Morandi C, Pentassuglia L, Heim P, Lebboukh S, Berthonneche C, Pedrazzini T, Kaufmann BA, Hall MN, Rüegg MA, Brink M.

Cardiovasc Res. 2016; PMID: 26598511

 

Comparative transcriptome profiling of the injured zebrafish and mouse hearts identifiesmiRNA-dependent repair pathways.

Crippa S, Nemir M, Ounzain S, Ibberson M, Berthonneche C, Sarre A, Boisset G, Maison D, Harshman K, Xenarios I, Diviani D, Schorderet D, Pedrazzini T.

Cardiovasc Res. 2016 May; PMID: 26857418

 

Super-enhancer lncs to cardiovascular development and disease.

Ounzain S, Pedrazzini T.

Biochim Biophys Acta. 2016 Jul; PMID: 26620798

Review

 

Divergent Paths Lnc Cell Fates.

Ounzain S, Pedrazzini T.

Cell Stem Cell. 2016 May; 27152437

Review

 

 


(2015)

CARMEN, a human super enhancer-associated long noncoding RNA controlling cardiacspecification, differentiation and homeostasis.

Ounzain S, Micheletti R, Arnan C, Plaisance I, Cecchi D, Schroen B, Reverter F, Alexanian M, Gonzales C, Ng SY, Bussotti G, Pezzuto I, Notredame C, Heymans S, Guigó R, Johnson R, Pedrazzini T.

J Mol Cell Cardiol. 2015 Dec; PMID: 26423156

 

Discovery and functional characterization of cardiovascular long noncoding RNAs.

Ounzain S, Burdet F, Ibberson M, Pedrazzini T.

J Mol Cell Cardiol. 2015 Dec; PMID: 26408097

Review

 

Jagged1 intracellular domain-mediated inhibition of Notch1 signalling regulates cardiachomeostasis in the postnatal heart.

Metrich M, Bezdek Pomey A, Berthonneche C, Sarre A, Nemir M, Pedrazzini T.

Cardiovasc Res. 2015 Oct; PMID: 26249804

 

 

The promise of enhancer-associated long noncoding RNAs in cardiac regeneration.

Ounzain S, Pedrazzini T.

Trends Cardiovasc Med. 2015 Oct; PMID: 25753179

Review

 

 

Long noncoding RNAs in cardiac development and ageing.

Devaux Y, Zangrando J, Schroen B, Creemers EE, Pedrazzini T, Chang CP, Dorn GW 2nd, Thum T, Heymans S; Cardiolinc network.

Nat Rev Cardiol. 2015 Jul; PMID: 25855606

Review

 

 

HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease.

Mirtschink P, Krishnan J, Grimm F, Sarre A, Hörl M, Kayikci M, Fankhauser N, Christinat Y, Cortijo C, Feehan O, Vukolic A, Sossalla S, Stehr SN, Ule J, Zamboni N, Pedrazzini T, Krek W.

Nature. 2015 Jun; PMID: 26083752

 

 

[In the heart of noncoding RNA: a long way to go].

Pedrazzini T.

Med Sci (Paris). 2015 Mar; PMID: 25855279

Review

 

Genome-wide profiling of the cardiac transcriptome after myocardial infarction identifiesnovel heart-specific long non-coding RNAs.

Ounzain S, Micheletti R, Beckmann T, Schroen B, Alexanian M, Pezzuto I, Crippa S, Nemir M, Sarre A, Johnson R, Dauvillier J, Burdet F, Ibberson M, Guigó R, Xenarios I, Heymans S, Pedrazzini T.

Eur Heart J. 2015 Feb; PMID: 24786300

 

 


(2014)

 

Functional importance of cardiac enhancer-associated noncoding RNAs in heartdevelopment and disease.

Ounzain S, Pezzuto I, Micheletti R, Burdet F, Sheta R, Nemir M, Gonzales C, Sarre A, Alexanian M, Blow MJ, May D, Johnson R, Dauvillier J, Pennacchio LA, Pedrazzini T.

J Mol Cell Cardiol. 2014 Nov; PMID: 25149110

 

 

The Notch pathway controls fibrotic and regenerative repair in the adult heart.

Nemir M, Metrich M, Plaisance I, Lepore M, Cruchet S, Berthonneche C, Sarre A, Radtke F, Pedrazzini T.

Eur Heart J. 2014 Aug; PMID: 23166366

 

 

Ageing-related cardiomyocyte functional decline is sex and angiotensin II dependent.

Mellor KM, Curl CL, Chandramouli C, Pedrazzini T, Wendt IR, Delbridge LM.

Age (Dordr). 2014 Jun; PMID: 24566994

 

 

Meeting highlights from the 2013 European Society of Cardiology Heart Failure AssociationWinter Meeting on Translational Heart Failure Research.

Hohl M, Ardehali H, Azuaje FJ, Breckenridge RA, Doehner W, Eaton P, Ehret GB, Fujita T, Gaetani R, Giacca M, Hasenfuß G, Heymans S, Leite-Moreira AF, Linke WA, Linz D, Lyon A, Mamas MA, Orešič M, Papp Z, Pedrazzini T, Piepoli M, Prosser B, Rizzuto R, Tarone G, Tian R, van Craenenbroeck E, van Rooij E, Wai T, Weiss G, Maack C.

Eur J Heart Fail. 2014 Jan; PMID: 24453095

 


(2013)

The AP-1 transcription factor c-Jun prevents stress-imposed maladaptive remodeling of the heart.

Windak R, Müller J, Felley A, Akhmedov A, Wagner EF, Pedrazzini T, Sumara G, Ricci R.

PLoS One. 2013 Sep; PMID: 24039904

 

 

Small and long non-coding RNAs in cardiac homeostasis and regeneration.

Ounzain S, Crippa S, Pedrazzini T.

Biochim Biophys Acta. 2013 Apr; PMID: 22951218

Review

 

 

Nitric oxide synthase 2 is required for conversion of pro-fibrogenic inflammatory CD133(+) progenitors into F4/80(+) macrophages in experimental autoimmune myocarditis.

Blyszczuk P, Berthonneche C, Behnke S, Glönkler M, Moch H, Pedrazzini T, Lüscher TF, Eriksson U, Kania G.

Cardiovasc Res. 2013 Feb; PMID: 23090609

 

 


(2012)

The Notch pathway controls fibrotic and regenerative repair in the adult heart.

Nemir M, Metrich M, Plaisance I, Lepore M, Cruchet S, Berthonneche C, Sarre A, Radtke F, Pedrazzini T.

Eur Heart J. 2014 Aug; PMID: 23166366

 

Dietary obesity-associated Hif1α activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ system.

Krishnan J, Danzer C, Simka T, Ukropec J, Walter KM, Kumpf S, Mirtschink P, Ukropcova B, Gasperikova D, Pedrazzini T, Krek W.

Genes Dev. 2012 Feb; PMID: 22302938

 

 

Cardiac dysfunction and impaired compensatory response to pressure overload in micedeficient in stem cell antigen-1.

Rosenblatt-Velin N, Ogay S, Felley A, Stanford WL, Pedrazzini T.

FASEB J. 2012 Jan; PMID: 21957128

 

Isolation of cardiovascular precursor cells from the human fetal heart.

Gonzales C, Ullrich ND, Gerber S, Berthonneche C, Niggli E, Pedrazzini T.

Tissue Eng Part A. 2012 Jan; PMID: 21902604

 

 

Mapping genetic variants associated with beta-adrenergic responses in inbred mice.

Hersch M, Peter B, Kang HM, Schüpfer F, Abriel H, Pedrazzini T, Eskin E, Beckmann JS, Bergmann S, Maurer F.

PLoS One. 2012; PMID: 22859963

 

 

Impact of salt on cardiac differential gene expression and coronary lesion in normotensivemineralocorticoid-treated mice.

Wang Q, Domenighetti AA, Schäfer SC, Weber J, Simon A, Maillard MP, Pedrazzini T, Chen J, Lehr HA, Burnier M.

Am J Physiol Regul Integr Comp Physiol. 2012; PMID: 22403797

 

 

Cardiac lineage protein-1 (CLP-1) regulates cardiac remodeling via transcriptionalmodulation of diverse hypertrophic and fibrotic responses and angiotensin II-transforming growth factor β (TGF-β1) signaling axis.

Mascareno E, Galatioto J, Rozenberg I, Salciccioli L, Kamran H, Lazar JM, Liu F, Pedrazzini T, Siddiqui MA.

J Biol Chem. 2012; PMID: 22308025

 

 

Differential effects of high-fat diet on myocardial lipid metabolism in failing and nonfailing hearts with angiotensin II-mediated cardiac remodeling in mice.

Pellieux C, Montessuit C, Papageorgiou I, Pedrazzini T, Lerch R.

Am J Physiol Heart Circ Physiol. 2012; PMID: 22408021